Research has shown that most homeless people suffer from weak support from family, relatives and friends. Based on a descriptive statistical analysis with biographical records of 810 subjects, and a thematic analysis of interviews with homeless people (N = 65), people at risk of homelessness (N = 5) and professionals (N = 20), the article explores the social support system of homeless people from Chisinau (Moldova). Only 18.6 per cent of all users of the Shelter for homeless in Chisinau were in a couple relationship (and only 5.6 per cent registered officially). For former detainees (23 per cent of the Shelter users) and care leavers (11 per cent), it is even more difficult to create a couple and to strengthen their social support network, as the institutions they come from did not foster their social support. As homelessness becomes chronic, people build social support networks with other homeless people. This social support helps homeless people to cope with stressful living conditions. The article suggests, in the case of Moldova, that social support relations with family, friends, acquaintances and other homeless people are affected negatively in the absence of policies and institutional measures targeted to encourage and strengthen such relationships.