It has been experimentally proved the existence of high insecticidal activity of the extract of Veratrum lobelianum BERNH. (0.1 to 0.5% of active substance) against imagoes and larvae of Leptinotarsa decemlineata SAY, larvae of the age I-III of Heliothis armigera HBN., Mamestra brassicae L., as well as against Acyrtho siphonpisum HARR. The extract shows high ovicidal (61.5 to 100%) and antifeedant (1-2 points) activity against L. decemlineata. It has been experimentally confirmed that the extract shows repellent activity against the larvae of G. mellonella. It has been proved that carrying out a single treatment with 0.1% extract of V. lobelianum (water-alcohol solution, 7.5 l/ha, 40 g/l of active substance) is enough to reduce the numerosity of L. decemlineata of the first generation. On the 21st day after being treated, the efficiency remained at reference level (92.0%), and plant damage did not exceed 5% (1 point). It has been determined that the treatment of potato plants with the extract of V. lobelianum has no negative impact onentomophages of Chrysopa carnea STEPH., Coccinella septempunctata L. and Zicrona caerulea L.: their numerosity remained at reference level and significantly exceeded chemical reference (by 1.5-4.0 times).