The North-western part of the Black Sea (NWBS) is an unique marine ecosystem. Characteristic features of the NWBS are fresh water input from the Danube. In the last 40 years the process of anthropogenic euthrophikation stimulated near bottom hypoxia linked with it, which stipulated large-scale benthos flora and fauna mortality. In addition to this negative phenomenon a lot of contamination and pollutants are carried by river flow into the sea. In the process of suspended matter sedimentation pollutants are accumulated in the bottom sediments. It worsens the condition of benthos organisms. This is the reason to view this problem using data base and possible literature to analyze the intensity, accumulation and distribution of pollutants, heavy metals and oil, including the NWBS shelf area. Modern investigations of the Danube Project are very important for understanding of the processes in the sea. The Danube input depends on marine environment. All ingredients coming from the river accumulate in the bottom sediments of the coastal zone. One of the most important ingredients of the aquatic systems is the level of oil concentration in water and bottom sediments. At present period there is intensive process of increasing of oil in the bottom sediments of the NWBS shelf. According to literature data, the average and typical value of oil concentration in the uncontaminated areas of the Black and Azov Seas in the 80s was 200 mg/kg. In the current period the highest values of oil concentration were marked in front of the Danube area with the values a little less than 200 mg/kg. In the current period oil concentration increased slightly up to 285 mg/kg, mercury concentrations in the Ukrainian and Romanian parts of the Danube region exceed the natural geochemical condition for the whole NWBS shelf 2 – 5 times. There is a positive factor to mark drastic reduction of cadmium concentration in the Danube region. In the period of 90s in Ukrainian part the concentration was very high – 6.2 mg/kg and at present the values make from 0.19 (Ukrainian part) to 1.71 (Romanian part) mg/kg. In the period of 1993 – 2013 nickel concentration in the Danube region was even less than in the whole NWBS shelf however compared with the period of the 80s the concentration increased by an order from 5.9 to 33.3 mg/kg. Zinc concentration in the period of the 90s in Ukrainian part exceeded the concentrations in Romanian part, but at the beginning of 2000s this ratio changed the opposite direction. The values of arsenic, phenols, chromium and cobalt concentrations are approximately of the same order both in Romanian and in the Ukrainian part of the Danube as well. Concentrations of mercury and zinc in the bottom sediments of the Danube region exceed the corresponding values on the NWBS shelf. Analyses of Ukrainian and Romanian data for different periods showed their good correlation, common order of the values and tendencies of temporal dynamics; commonly that reflected causal regularities of natural variation and anthropogenic influences on the aquatic systems.