Juglone is a naphthoquinone compound present in high amounts in the plants of the family
Juglandaceae. Especially high amounts can be detected in the eastern black walnut (Juglans nigra)
and common walnut (Juglans regia).
Juglone has a wide spectrum of biological activity, including antibacterial and antifungal properties
[1].
The aim of our study was to obtain new compounds derivated from juglone, which could potentially
have interesting biological properties. For this reason, a reaction was carried out between 2-
hydroxy-juglone 1 with perillaldehyde 2. We expected the formation of compound 3, but the 1Н-,
13С-NMR data indicated the formation of another one. The identity of it has been established by
additional experiments including those two-dimensional (COSY, HSQC, HMBC, NOE). Moreover, the
structure 4 was confirmed by X-ray analysis.

Scheme. The synthesis of juglone derivative 4.
ACKNOWLEDGMENTS
The authors are grateful for the funding offered by the National Agency for Research and
Development of the Republic of Moldova under the project 19.80012.80.07А.
REFERENCES
[1]. M. Strugstad. Journal of Ecosystems and Management 2012, 13, 3, 72–82.