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<creators>
<creator>
<creatorName>Morărescu (Chetraru), O.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Grinco, M.C.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Lunganu, M.I.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Ungur, N.D.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>NaIO4/LiBr-supported functionalization of ENT-KAUR-16-EN-19-OIC acid</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2015</publicationYear>
<relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'></relatedIdentifier>
<dates>
<date dateType='Issued'>2015</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>The scientific interest in diterpenic tetracyclic ent-kaur-16-en-19-oic acid (1) is explained by the fact that this compound possesses a broad spectrum of biological activities [1-3]. It was isolated from different vegetal sources, especially from sunflower Helianthus sp. [4]. Polyfunctionalized tetracyclic ent-kauranic terpenoids are also of a great interest, as a result of their pronounced biological activity. For the functionalization of ent-kaur-16-en-19-oic acid (1) the catalytic version of Prevost - Woodward reaction was used. We report herein the results of the transformation of ent-kaur-16-en-19-oic acid (1) catalyzed by LiBr and mediated by NaIO4, using the method described in the literature [5]. As a result, a mixture of diterpenic compounds was obtained, which was purified by column chromatography, resulting in the isolation of the functionalized ent-kauranic diterpenoids (2) &ndash; (6). Their structures were elucidated by NMR and IR spectroscopies. It should be mentioned, that diterpenoids (2), (3) and (5) containing a bromine atom at C-17 can potentially be endowed with interesting biological properties.</p><p>figure</p><p>Figure 1. Functionalization of ent-kaur-16-en-19-oic acid. As a result of Prevost&ndash;Woodward transformation of ent-kaur-16-en-19-oic acid (1), new derivatives of ent-kaurenic acid, functionalized at C-15, C-16 and C-17 carbon atoms, have been obtained.</p></description>
</descriptions>
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<format>application/pdf</format>
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