| Articolul precedent |
| Articolul urmator |
 |
 715 1 |
| Ultima descărcare din IBN: 2021-01-27 14:49 |
 SM ISO690:2012MORĂRESCU (CHETRARU), Olga, GRINCO, Marina, LUNGANU, Maria, UNGUR, Nikon. NaIO4/LiBr-supported functionalization of ENT-KAUR-16-EN-19-OIC acid. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 108. |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
| Physical Methods in Coordination and Supramolecular Chemistry XVIII, 2015 |
||||||
|
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry"" Chişinău, Moldova, 8-9 octombrie 2015 | ||||||
|
||||||
| Pag. 108-108 | ||||||
|
||||||
 Descarcă PDF |
||||||
| Rezumat | ||||||
The scientific interest in diterpenic tetracyclic ent-kaur-16-en-19-oic acid (1) is explained by the fact that this compound possesses a broad spectrum of biological activities [1-3]. It was isolated from different vegetal sources, especially from sunflower Helianthus sp. [4]. Polyfunctionalized tetracyclic ent-kauranic terpenoids are also of a great interest, as a result of their pronounced biological activity. For the functionalization of ent-kaur-16-en-19-oic acid (1) the catalytic version of Prevost - Woodward reaction was used. We report herein the results of the transformation of ent-kaur-16-en-19-oic acid (1) catalyzed by LiBr and mediated by NaIO4, using the method described in the literature [5]. As a result, a mixture of diterpenic compounds was obtained, which was purified by column chromatography, resulting in the isolation of the functionalized ent-kauranic diterpenoids (2) – (6). Their structures were elucidated by NMR and IR spectroscopies. It should be mentioned, that diterpenoids (2), (3) and (5) containing a bromine atom at C-17 can potentially be endowed with interesting biological properties.figureFigure 1. Functionalization of ent-kaur-16-en-19-oic acid. As a result of Prevost–Woodward transformation of ent-kaur-16-en-19-oic acid (1), new derivatives of ent-kaurenic acid, functionalized at C-15, C-16 and C-17 carbon atoms, have been obtained. |
||||||
|
Cerif XML Export
<?xml version='1.0' encoding='utf-8'?> <CERIF xmlns='urn:xmlns:org:eurocris:cerif-1.5-1' xsi:schemaLocation='urn:xmlns:org:eurocris:cerif-1.5-1 http://www.eurocris.org/Uploads/Web%20pages/CERIF-1.5/CERIF_1.5_1.xsd' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' release='1.5' date='2012-10-07' sourceDatabase='Output Profile'> <cfResPubl> <cfResPublId>ibn-ResPubl-101805</cfResPublId> <cfResPublDate>2015</cfResPublDate> <cfVol>XVIII</cfVol> <cfStartPage>108</cfStartPage> <cfISBN></cfISBN> <cfURI>https://ibn.idsi.md/ro/vizualizare_articol/101805</cfURI> <cfTitle cfLangCode='EN' cfTrans='o'>NaIO4/LiBr-supported functionalization of ENT-KAUR-16-EN-19-OIC acid</cfTitle> <cfAbstr cfLangCode='EN' cfTrans='o'><p>The scientific interest in diterpenic tetracyclic ent-kaur-16-en-19-oic acid (1) is explained by the fact that this compound possesses a broad spectrum of biological activities [1-3]. It was isolated from different vegetal sources, especially from sunflower Helianthus sp. [4]. Polyfunctionalized tetracyclic ent-kauranic terpenoids are also of a great interest, as a result of their pronounced biological activity. For the functionalization of ent-kaur-16-en-19-oic acid (1) the catalytic version of Prevost - Woodward reaction was used. We report herein the results of the transformation of ent-kaur-16-en-19-oic acid (1) catalyzed by LiBr and mediated by NaIO4, using the method described in the literature [5]. As a result, a mixture of diterpenic compounds was obtained, which was purified by column chromatography, resulting in the isolation of the functionalized ent-kauranic diterpenoids (2) – (6). Their structures were elucidated by NMR and IR spectroscopies. It should be mentioned, that diterpenoids (2), (3) and (5) containing a bromine atom at C-17 can potentially be endowed with interesting biological properties.</p><p>figure</p><p>Figure 1. Functionalization of ent-kaur-16-en-19-oic acid. As a result of Prevost–Woodward transformation of ent-kaur-16-en-19-oic acid (1), new derivatives of ent-kaurenic acid, functionalized at C-15, C-16 and C-17 carbon atoms, have been obtained.</p></cfAbstr> <cfResPubl_Class> <cfClassId>eda2d9e9-34c5-11e1-b86c-0800200c9a66</cfClassId> <cfClassSchemeId>759af938-34ae-11e1-b86c-0800200c9a66</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> </cfResPubl_Class> <cfResPubl_Class> <cfClassId>e601872f-4b7e-4d88-929f-7df027b226c9</cfClassId> <cfClassSchemeId>40e90e2f-446d-460a-98e5-5dce57550c48</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> </cfResPubl_Class> <cfPers_ResPubl> <cfPersId>ibn-person-12492</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> </cfPers_ResPubl> <cfPers_ResPubl> <cfPersId>ibn-person-12130</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> </cfPers_ResPubl> <cfPers_ResPubl> <cfPersId>ibn-person-41014</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> </cfPers_ResPubl> <cfPers_ResPubl> <cfPersId>ibn-person-672</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> </cfPers_ResPubl> </cfResPubl> <cfPers> <cfPersId>ibn-Pers-12492</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-12492-3</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> <cfFamilyNames>Морареску</cfFamilyNames> <cfFirstNames>Ольга</cfFirstNames> </cfPersName_Pers> </cfPers> <cfPers> <cfPersId>ibn-Pers-12130</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-12130-3</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> <cfFamilyNames>Гринько</cfFamilyNames> <cfFirstNames>Марина</cfFirstNames> </cfPersName_Pers> </cfPers> <cfPers> <cfPersId>ibn-Pers-41014</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-41014-3</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> <cfFamilyNames>Lunganu</cfFamilyNames> <cfFirstNames>Maria</cfFirstNames> </cfPersName_Pers> </cfPers> <cfPers> <cfPersId>ibn-Pers-672</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-672-3</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2015T24:00:00</cfStartDate> <cfFamilyNames>Ungur</cfFamilyNames> <cfFirstNames>Nikon</cfFirstNames> <cfFamilyNames>Унгур</cfFamilyNames> <cfFirstNames>Никон</cfFirstNames> </cfPersName_Pers> </cfPers> </CERIF>
|
|
|
