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<oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'>
<dc:creator>Lungu, L.V.</dc:creator>
<dc:creator>Arîcu, A.N.</dc:creator>
<dc:creator>Ciocârlan, A.G.</dc:creator>
<dc:creator>Şova, S.G.</dc:creator>
<dc:creator>Zbancioc, G.</dc:creator>
<dc:creator>Mangalagiu, I.</dc:creator>
<dc:creator>Vornicu, N.</dc:creator>
<dc:date>2015</dc:date>
<dc:description xml:lang='en'><p>The results of investigations devoted to the synthesis of new drimanic compound containing heterocyclic structural units are reported. The 11,12-p-tolyl-pyridazonyl-drim5(6),8(9)-en-7-one 3 was prepared by interaction of bromide 1 with p-tolyl-pyridazone 2 under depicted conditions.1 As result of &ldquo;in vitro&rdquo; biological assessment tested compound 3 showed exceptional activity against five strains of fungi (Aspergillus flavus, Fusarium solani, Penicillium chrysogenum, P. frequentans, Alternaria alternata) and against both Gram-positive (Bacillus polymyxa) and Gram-negative (Pseudomonas aeruginosa) bacteria at MIC values 510-3 &mu;g/mL and 3.210-2 &mu;g/mL, respectively.2</p><p>figure</p><p>Scheme 1. Reagents and conditions: K2CO3, DMAA, r.t., 24h, 77%. The structure and stereochemistry of the compound 3 was confirmed unambiguously by X-ray diffraction on monocrystal (Figure 1). According to single crystal X-ray study compound 3 crystallizes in C2 space group of monoclinic system comprising two crystallographic asymmetric but chemically equivalent molecular entities (denoted A and B). One of the azaheterocyclic fragments in molecule A, as well as the whole molecule B, were found to be disordered into two resolvable positions in 1:1 ratio.3</p><p>Figure 1. The X-ray molecular structure of compound 3. H atoms are omitted for clarity</p></dc:description>
<dc:source>Physical Methods in Coordination and Supramolecular Chemistry (XVIII) 93-93</dc:source>
<dc:title>Synthesis, biological activity and X-ray analysis of 11,12-p-tolyl-pyridazonyl-drim-5(6),8(9)-en-7-one</dc:title>
<dc:type>info:eu-repo/semantics/article</dc:type>
</oai_dc:dc>