Pyrrolo[1,2-a]quinoxaline skeleton is a constituent of several bioactive compounds that demonstrated anti-HIV and anticancer activities. Pyrrolo[1,2-a]benzimidazole derivatives exhibit activity against a variety of cancer cell lines and were found to be useful in treating central nervous system disorders These properties lead to a constant interest in developing more efficient ways for the synthesis of these heterocyclic systems.  We report here several new pyrrolo[1,2-a]quinoxaline and benzimidazole derivatives obtained through an one-pot three component reaction. The structures of newly synthesized derivatives were assigned by NMR spectroscopy using several 1D and 2D experiments.