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Нервная система. Невропатология. Неврология (490) |
SM ISO690:2012 CRACEA (DRUŞCA), Angela, REVENCO, Ninel. Influenţa tratamentului cu preparatul antioxidant Vita grapes asupra indicilor prooxidanţi în artrita juvenilă idiopatică. In: Buletin de Perinatologie, 2019, nr. 2(83), pp. 89-93. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 2(83) / 2019 / ISSN 1810-5289 | ||||||
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CZU: 616.72-002.77-053.2-071-085 | ||||||
Pag. 89-93 | ||||||
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Juvenile Idiopathic Arthritis is considered a chronic disease, disabling, with a high socio-economic impact. In idiopathic juvenile arthritis, the production of free radicals of oxygen exceeds the antioxidant capacity of the cells. Free oxygen radicals attack lipids, proteins, DNA by peroxidation reactions. A biomarker of oxidative stress is considered to be malondialdehyde – an aldehyde that occurs in the body following the degradation of polyunsaturated fatty acids in the absence of antioxidants. Material and methods. 50 patients with Juvenile Idiopathic Arthritis were selected. Th e children were divided into 4 groups: group I ‒ 14 children with Juvenile Idiopathic Arthritis who received treatment with Metotrexat and Vita Grapes ‒ antioxidant drug; group II ‒ 12 children treated with Metotrexate, Prednisolone and Vita Grapes; group III ‒ 11 children only treated with Methotrexate; group IV ‒ 13 children treated with Metotrexate and Prednisolone. Results. Aft er 3 months of treatment, prooxidant indicators were analyzed between groups, and their values were reduced in groups I and II, which administered Vita Grapes the antioxidant drug compared to groups III and IV that did not receive the antioxidant drug (p> 0,05). Conclusions. Vita Grapes has antioxidant action, increasing the antioxidant capacity of the body and decreasing the values of prooxidant indicators. |
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Cuvinte-cheie Juvenile idiopathic arthritis, prooxidant indicators, treatment, идиопатический ювенильный артрит, прооксидантивные показатели, лечение, artrită juvenilă idiopatică, indici prooxidanți, Tratament |
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