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<oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'>
<dc:creator>Schuurmann, G.</dc:creator>
<dc:date>2017</dc:date>
<dc:description xml:lang='en'><p>Through the European Directive REACH in 2007, alternative methods have gained increased importance as non-animal tools for the toxicological assessment of chemical compounds. In this context, the 3R principle of reducing, refining and replacing animal testing has resulted in a paradigm shift toward integrated testing strategies (ITS) that aim at exploiting the combined information generated from several non-animal methods in order to &ndash; partly or fully &ndash; replace a given animal experiment. In the presentation, respective non-test (in silico) and test (in chemico, in vitro) methods are outlined for industrial chemicals and pharmaceuticals, focussing on chemoassays,1 read-across,2 structural alerts,3 computational chemistry,4 and chemoavailability5 for predicting reactive toxicity and metabolic acti-vation through P450 catalysis.</p></dc:description>
<dc:source>Ecological and environmental chemistry  (Ediția 6) 51-51</dc:source>
<dc:title>Predictive assessment of the human and environmental toxicity of chemical substances</dc:title>
<dc:type>info:eu-repo/semantics/article</dc:type>
</oai_dc:dc>