Stanca–Costești reservoir is a protected area (SPA) situated in the North-Eastern Romania. It is one of the biggest water accumulations in Romania (the second one after the Iron Gates I), and the biggest one on the Prut River. The fish from the lake represent a major food resource for the local people and not only, have they being commercialized even in Iasi markets. Heavy metals are accumulated by aquatic organisms by a variety of methods, including respiration, absorption or ingestion. Fish are good indicators of the accumulation of metals in the environment. Heavy metal pollution is the main topic addressed in this paper due to the toxicity of these elements for the aquatic organisms. The metal analyzes were conducted with the GF-HR-CS-AAS contrAA600 - Analytik Jena, Germany. These methods allowed us to quantify the metal content of samples in the range interval of 10 ng*g-1 - 0.5 μg*g-1. According to our study results, focused on four fish species (Abramis brama, Stizostedion lucioperca, Hypophthalmichthys nobilis and Aspius aspius) copper was accumulated in the highest concentration in the gut (3.13 mg.kg-1) and in the intestinal content (2.374 mg.kg-1) for avat, in liver (56.138 mg.kg-1) for bighead carp, in liver (0.879 mg.kg-1) and in femel gonads (0.870 mg.kg-1) for pearch and in intestine (3.551 mg.kg-1) and femel gonads (3.007 mg.kg-1) for bream. Cadmium was accumulated in the highest concentration in the intestinal contents (0.071 mg.kg-1) and in intestine (0.055 mg.kg-1) for avat, in kidney (1.419 mg.kg-1) and liver (1.027 mg.kg-1) for bighead carp, in liver (0.328 mg.kg-1) for pearch and in intestine (0.194 mg.kg-1) for pearch. Selenium has accumulated in the highest concentration in the tail fin (2.486 mg.kg-1) for avat, in bone (1.678 mg.kg-1) for bighead carp, in stomacal content (2.468 mg.kg-1) for pearch and in bone (2.642 mg.kg-1) for bream. Acknowledgements This work was partially funded by the “Alexandru Ioan Cuza” University of Iasi, the project no. GI-2015-11, Grants competition for young researchers UAIC