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SM ISO690:2012 GALE, Jeremy D., BERGER, Brian B., GILBERT, Steven, POPA, Serghei, SULTAN, Marla B., SCHACHAR, Ronald A., GIRGENTI, Douglas Q., PERROS-HUGUET, Christelle. A CCR2/5 inhibitor, PF-04634817, is inferior to monthly ranibizumab in the treatment of diabetic macular edema. In: Investigative Ophthalmology and Visual Science, 2018, nr. 6(59), pp. 2659-2669. ISSN 0146-0404. DOI: https://doi.org/10.1167/iovs.17-22731 |
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Investigative Ophthalmology and Visual Science | |
Numărul 6(59) / 2018 / ISSN 0146-0404 | |
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DOI:https://doi.org/10.1167/iovs.17-22731 | |
Pag. 2659-2669 | |
Rezumat | |
PURPOSE. Ligands for the proinflammatory C-C chemokine receptor types 2 and 5 (CCR2 and CCR5) are elevated in the eyes of patients with diabetic macular edema (DME). We evaluated the efficacy and safety of PF-04634817, an oral CCR2/5 dual antagonist, versus intravitreal ranibizumab, in adult subjects with DME. METHODS. In this phase II, randomized, placebo-controlled, double-masked study, eligible subjects (≥18 years of age) had type 1 or 2 diabetes and DME with best-corrected visual acuity (BCVA) of 20/32 or worse (letter score ≤ 78), and up to 20/320 or better (≥24 letter score), in the study eye. Subjects were assigned randomly 1:1 to once-daily (QD) oral PF-04634817 200 mg plus masked sham therapy as placebo or monthly intravitreal ranibizumab 0.3/0.5 mg plus QD oral placebo. The primary objective was to evaluate the efficacy of PF-04634817 compared with ranibizumab in change from baseline in BCVA after 12 weeks in a noninferiority design. Noninferiority was based on BCVA 80% confidence interval (CI): there had to be a less than three letter loss in the PF-04634817 arm compared with the ranibizumab arm. RESULTS. A total of 199 subjects were randomized. Least squares mean difference in change in BCVA from baseline to week 12 in the study eye for the PF-04634817 arm was -2.41 letters (80% CI: -3.91, -0.91; P = 0.04) compared with ranibizumab. PF-04634817 was well tolerated. CONCLUSIONS. Treatment with oral CCR2/5 receptor dual antagonist PF-04634817 was associated with a modest improvement in BCVA, but did not meet the predefined noninferiority criteria compared with intravitreal ranibizumab. |
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Cuvinte-cheie CCR2, CCR5, Diabetic macular edema, diabetes, visual acuity |
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