Introduction. This research aims to investigate and offer perspectives on vaccination plans and tactics for children with primary immune deficiency (PIDs), tackling particular difficulties and refining immunization procedures to improve defenses in this susceptible group. Objective of the study: to evaluate the safety, efficacy, and optimal vaccination strategies for children with PIDs, with the goal of improving immune response, preventing vaccine-preventable diseases, and improving overall health outcomes in this vulnerable population. Material and methods. The data from online databases and international journals on the course vaccination in children with PIDs the basis of the field’s literature review obtained from a variety of sources like electronic libraries such as UpToDate, BMC, Periodicum Biologorum and NIH public access. Results. The literature revealed a range of viewpoints on vaccinating children with PIDs. Immunization plays a critical role in safeguarding individuals with primary immunodeficiency disorders (PID) against severe infections. However, the efficacy of vaccines can fluctuate significantly among PID patients. While some exhibit robust immune responses (ex, hyper-Ig M syndrome, selected antibody deficiencies, partial combined immunodeficiencies etc.), others encounter compromised reactions or adverse effects (like-Hyper-Ig E syndrome, DiGeorge syndrome, Common variable immunodeficiency etc.). Current recommendations advocate for the use of inactivated vaccines, deemed safe for this demographic. Notably, live vaccines like BCG and MMR are cautioned in cases of severe combined immunodeficiency, like Ommen syndrome, X-linked SCID, Reticular dysgenesis etc. Further investigation is warranted to delineate the most effective vaccination strategies for this susceptible cohort. Conclusions. To sum up, customized vaccination strategies, vigilant monitoring, and prompt diagnosis are imperative in safeguarding PID patients while mitigating the potential risks associated with immunization and establishing the necessary immune response towards vaccines.