New minor diterpenoid diacylglycerols from the skin of the nudibranch Anisodoris fontaini
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GAVAGNIN, M, UNGUR, Nikon, CASTELLUCCIO, Francesco, MUNIAIN, Claudia C., CIMINO, Guido. New minor diterpenoid diacylglycerols from the skin of the nudibranch Anisodoris fontaini. In: Journal of Natural Products, 1999, vol. 62, pp. 269-274. ISSN 0163-3864. DOI: https://doi.org/10.1021/np980344r
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Journal of Natural Products
Volumul 62 / 1999 / ISSN 0163-3864 /ISSNe 1520-6025

New minor diterpenoid diacylglycerols from the skin of the nudibranch Anisodoris fontaini

DOI:https://doi.org/10.1021/np980344r

Pag. 269-274

Gavagnin M1, Ungur Nikon2, Castelluccio Francesco1, Muniain Claudia C.3, Cimino Guido1
 
1 Instituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Napoli,
2 Institute of Chemistry of the Academy of Sciences of Moldova,
3 University of Oviedo
 
 
Disponibil în IBN: 19 iunie 2024


Rezumat

The Patagonian riorid nudibranch Anisodoris fontaini contains in its mantle a series of isocopalane diterpenoid diacylglycerols. Five new minor metabolites, anisodorins 1-5 (1-5), along with the already reported 6 and 7, have been isolated and chemically characterized. The structure and the relative stereochemistries have been determined by spectroscopic means, while the absolute stereochemistries for 2-5 are suggested to be the same as for the biogenetically related major compounds 6 and 7. Synthesis of the enantiomer (8) of anisodorin 1 confirmed the proposed structure and absolute stereochemistry.

Cuvinte-cheie
EMTREE drug terms anisodorin, diacylglycerol derivative, diterpenoid, unclassified drug EMTREE medical terms article, carbon nuclear magnetic resonance, Chemical analysis, drug isolation, high performance liquid chromatography, mollusc, proton nuclear magnetic resonance, spectroscopy, stereochemistry