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SM ISO690:2012 GĂINĂ, J., KOSUBA, R.. Коррекция милдронатом морфофункционального состояния почек при доксорубициновой нефропатии. In: Curierul Medical, 2013, nr. 1(56), pp. 29-32. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 1(56) / 2013 / ISSN 1875-0666 | ||||||
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Pag. 29-32 | ||||||
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The study has been made on white non-linear male rats weighing 150-170 gr. Three series of experiments were made: in the first one, the animals were injected with Doxorubicine (Ukraine, “Kievmedpreparat”, 5 mg/kg, intramuscular, once every seven days, four times); in the second one, the animals were injected with mildronate (Latvia, “Grindex”, 50 mg/kg, intraperitoneally, 28 days) against the background of Doxorubicine injection; in the third series (the control), water was injected into the animals (in similar volume) instead of medications. The regime of Doxorubicine injection chosen by the researchers has been used by scientists to simulate Doxorubicine cardiopathy. The function of the kidneys was studied 30 minutes after the last injection
of the preparations against water loading (5% of the animals’ body mass). On the 28-th day of the experiment, the kidneys were taken for morphogenetic investigations. Under the influence of Doxorubicine, the speed of glomerular filtration decreased, creatinine concentration in blood plasma increased, and
expressed proteinuria combined with the reduction of sodium and potassium ions excreted with urine. Usage of Mildronate together with Doxorubicine in the injection course prevents nephrotoxic effects of Doxorubicine. The findings of morphohistologic studies of the kidneys corroborated nephroprotective properties of mildronate. |
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Cuvinte-cheie Mildronate, Doxorubicine nephropathy, rats. |
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