In the recent years, it was registered a significant increase of the infection of cattle with fasciolosis. Adult cattle (4-6 years) during 1981-1982 were infected with fasciolosis in 32.1% of cases, and in 2010-2011 - in 66.5% of cases, which is higer by 34.4%, and these indices of young animals (23-25 months), were 16.2%, 47.1% and 30.9%, respectively. The reason, of it was grazing of animals of different species and ages in the limited territories. Fasciolosis infection of the cattle forms parasitocenosis of fasciola, opportunistic and pathogenic bacteria (Escherichia coli, Staphylococcus albus, Streptococcus viridans, Bacteria prоteus vulgaris etc.). It was found, that at the cattle infested with fasciolosis, the content of vitamin A in the liver decreased by 1.4 times, E - 3.18, B1 and B2 - 1.08 and 1.23, respectively, and C - 2.08, iron - by 3.01 times, phosphorus - 4.17, calcium - 1.56, Mg - 1.04, and the content of Na and K increased by 1.61 and 1.25 times compared to healthy non-infected animals. In the animals meat infected with fasciolosis the content of vitamin A was 1.83 times lower, E - 1.67, B1 - 1.21, B2 - 1.11, C - 3.73, calcium - 1.60, phosphorus - 1,46, but magnesia, sodium, potassium, and iron, respectively by 1.34, 1.82, 1.30 and 3.14 times higher, than in healthy cows. It has been established that in the animals infested with fasciola, profound morpho-physiological changes occur in the body, and the quality indicators of meat and organs (content of vitamins, micro- and macroelements, increased microbial contamination) are diminished, which require their commercialization only after industrial processing.