This article describes a method that can be used in experimental dentistry for investigations of osteointegration processes of dental implants. The procedure was patented (Invention BOPI AGEPI MD nr.12.2010). The researches accomplished below represent a component part of the subject area consecrated to the Evaluation of coordinative compounds of Zink and Vanadium at the stimulation of osteo-regenerative processes in periodontal tissues and at the application of dental implants. Experimental investigation included experiments carried out on 280 white rats. There were taken for the study 24 substances that contained Zink, Vanadium and Nickel. Testing of the influence of some new coordinative compounds of transitive metals (Zn, V, Ni) on osteo-regenerative processes in normal physiological conditions was determined in bone tissues of periodontium and femoral bones were extracted later on used for the determination of principal biochemical indices of bone tissue. There has been determined the most active biologic coordinative compound Zn(CF3CO2)2(γPic)2 (InventionNr. 950188 AGEPI MD) in regenerative processes of periodontal tissues during the modeling of experimental periodontitis. 57 patients with diverse periodontal diseases were subjected to the study. A profound investigation of biochemical indices of 27 patients was accomplished; out of them 15 patients were inserted dental implants. Zink picolinate was administrated per os 1 x 3 times a day before meals. The duration of the treatment was 30 days.