Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
1369 7 |
Ultima descărcare din IBN: 2023-01-05 12:05 |
SM ISO690:2012 LÎSÎI, Leonid, PROTOPOP, Svetlana, BOBCOVA, Svetlana, STRATULAT, Silvia, AMBROS, Ala, ZOTA, Larisa. Iodtironin selenodeiodinazele şi homeostazia axului hipotalamo-hipofizaro-tiroidian
. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2008, nr. 1(9), pp. 162-168. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(9) / 2008 / ISSN 1857-1719 | ||||||
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Pag. 162-168 | ||||||
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The iodothyronine selenodeiodinases and set-point of the hypothalamic-pituitary-thyroid axis
The goal of this review is to place the existing knowledge regarding the types 1, 2, and 3 (D1, D2, and D3, respectively) iodothyronine deiodinases into a biochemical context. This article reviews new data regarding the mechanism of selenoprotein synthesis, the molecular and cellular biological properties of the individual deiodinases, including tissue distribution, subcellular localization, enzymatic properties, and regulation of synthesis, inactivation, and degradation. Also the molecular mechanisms are elucidated through which the deiodinases regulate the
thyrotropin secretion, the homeostasis of circulating and intracellular triiodthyronine. |
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