Purpose The histopathologic evaluation of the implanted antiglaucoma shunt with valve in the rabbit’s eyes. Methods The preclinical research included the implantation of the newly designed antiglaucoma shunt with silicone valve made from PMMA (Polymethyl methacrylate which is a biocompatible material with ocular tissue) into the anterior chamber under a scleral flap. The surgery was performed on steroid-induced hypertension at the eye of New Zealand rabbits, divided into 2 groups (Group A- undergoes filtering device implantation) and Group B (served as control and undergoes trabeculectomy). Five eyes from each group were evaluated histopathologically following rabbits’ euthanasia on days 90 after antiglaucoma surgery. Results The ocular tissue reaction to PMMA device consisted of a fibrotic capsule, with an amount of fibroblasts in the study group compared with the control one. The samples were devoid of inflammatory cells (such as macrophages and lymphocytes). The lumen of the antiglaucoma shunt with valve was free of inflammatory exudates or other obstructions in all specimens examined. No adverse reactions were registered in Group A for up to 90 days. Conclusions The data obtained from the histopathologic examination reveals the good tolerability and safety of the antiglaucoma shunt with valve, with no adverse effects and inflammatory response. The device can be an alternative to trabeculectomy.