Introduction. Optimal treatment approaches for locally advanced prostate cancer remain controversial and there are currently no standard treatments. According to recent papers, radical prostatectomy in men with locally advanced prostate cancers seems to effect improvement in both cancer specific and overall survival rates in comparison to radiation with androgen deprivation therapy. The aim. This study was to report oncological outcomes of patients who underwent radical prostatectomy in our department and to assess the role of radical prostatectomy in patients with locally advanced prostate cancer. Methods. This study included 150 consecutive patients who underwent radical prostatectomy in our department. Oncologic outcomes comprised positive surgical margins, nodal involvement, ISUP grade, presence of perineural and lymphovascular invasion. Results. Median age of the patients was 65±4 (51-79) years. Based on postoperative pathology, form 150 patients, 51 (34%) were pT3, from whom 37% (19) pT3a and 63% (32) pT3b. The rates of positive surgical margins in the entire cohort with stage pT3 disease was 20% (10), N1 were 13,7% (7). In pT3a R1 were 5,2% (1), in pT3b R1were 28% (9), N1were18,7% (6). ISUP 1: 5,88% (3), ISUP 2: 27,45% (14), ISUP 3: 39,21% (20), ISUP 4: 13,7% (7), ISUP 5: 17,64% (9). Perineural invasion was present in 96% (49) of cases, limfovascular in 43,13% (22). Conclusions. Radical prostatectomy could be an option for patients with locally advanced prostate cancer.