The current practice in the treatment of cervical cancer
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RUSU, Ghenadie. The current practice in the treatment of cervical cancer. In: Міжнародний медико-фармацевтичний конгрес студентів і молодих учених: BIMCO, Ed. 1, 11-15 martie 2023, Chernivtsi. Chernivtsi: Bukovinian State Medical University, 2023, p. 163. ISSN 2616-5392.
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Міжнародний медико-фармацевтичний конгрес студентів і молодих учених 2023
Conferința " Міжнародний медико-фармацевтичний конгрес студентів і молодих учених"
1, Chernivtsi, Ucraina, 11-15 martie 2023

The current practice in the treatment of cervical cancer


Pag. 163-163

Rusu Ghenadie
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
 
Disponibil în IBN: 19 martie 2024


Rezumat

According to latest data cervical cancer is the fourth most common cancer in women worldwide, representing the leading cancer related death in most of the developing and low-resources countries. Presently the treatment process is highly complex and dependent on the stages of disease and patient individual characteristics. Aim of the study: to explore the current practice in the area of cervical cancer treatment Currently pre-cancer lesions therapy is focused on ablative treatment (thermal coagulation or cryotherapy) or excisional. The cervical cancer treatment generally follows FIGO 2018 staging. Stage IA1 involves conization or hysterectomy, with recurrences rate of 8.3%. In stages IA2 to IB2 standard procedures refer to radical hysterectomy (gold standard: open approach) and bilateral salpingectomy, 5-year overall survival rate exceeding 90%. Chemoradiotherapy might be suitable for patients unfit for surgery. Radical trachelectomy is an option to preserve fertility. The standard treatment approach in stages IB3 to IVA involve external pelvic radiation therapy, intracavitary brachytherapy and concurrent chemotherapy, with a survival rate between 24% to 76% depending on complications and therapy combinations. IVB stage (incurable) requires mainly chemotherapy, with a median survival rate of 6.1-59.4% depending on metastasis complexity. Most of the traditional therapies still have numerous limitations, including: non-specificity, reduced efficacy in the long-term, negative side effects etc. Cervical cancer therapy is evolving. Robotic laparoscopy become accessible. Combinations of radiation chemotherapy are continuously optimised. Modern radiation techniques focus on targeted dose, combining intracavitary and interstitial radiotherapy. Treatment techniques, in research phase, refer to: nanotechnology assisted chemotherapy, new immune checkpoint inhibitors, vaccines with immune reaction to E6 and E7 HPV's proteins, development of targeted drugs etc. The study was performed based on review of related retrospective researches and various scientific materials (articles in specialised journals, monographs, national protocols and standards, articles on the Internet etc.). The cervical cancer treatment concepts are complex and evolving rapidly to overcome the limitations of traditional methods. Novel treatment strategies are stringently needed, being more focused on targeted therapies, as well ason combination of existing techniques to increase their efficiency.