This paper constitutes a scientific approach, where there have been highlighted the most important innovative changes that influence the development of a higher education institution and shape the activity of universities towards permanent adaptation to achieve their sustainability. The topicality of the research topic stems from the need to identify effective measures to achieve sustainability in higher education institutions. The aim of the research is to identify the innovative changes that have a positive impact on the strategic development of the universities. The problem of the research lies in highlighting the most important innovative changes that can affect the universities in achieving their sustainability. In this context, we can reiterate that innovative changes have been defined and analysed from the perspective of the need of university change in the direction of their assimilation within institutions. In addition, the innovative potential of the Republic of Moldova was evaluated from the perspective of the analysis of the categories of scientific researchers, of the research fields, of the expenses undertaken by the state for the development of scientific researches. The research methodology focused on the use of several methods: analysis, synthesis, induction, abduction, deduction, qualitative research through documentation, scientific abstraction. In conclusion, we can reiterate that the Republic of Moldova has a valuable innovation potential, which can lead the country to achieve sustainability. The best solution would be the efficient capitalization of the innovative potential of the country but also its direction towards ensuring an ecological-economic-social balanc