Introduction. Inflammation is central to pathogenic processes in type 1 diabetes mellitus (T1DM). Objective. We aimed to correlate glycated hemoglobin (HbA1c) levels and markers of systemic inflammation in T1DM children. Methods. A total of 45 children with T1D (aged 10-18 years; gender M(20)/F(25); duration of T1D ≥ 5 years; insulin therapy) and control group - 45 patients (aged 10-18 years; gender M(19)/F(26)), were included in this study. The cytokine profile (proinflammatory cytokines) was estimated by determining the serum concentration of TNF-α, IL-1β, and IL-6. The results were considered significant when the p-value was less than 0.05. The statistical analysis was done by SPSS statistical package version 20.0. The study protocol was approved by the Research Ethics Committee of the "Nicolae Testemitanu" SUMPh. Results. The mean ± SD of IL-1β, IL-6 and TNF-α were: IL-1β =5.65±0.25 mmol/l, for T1DM (boys=5.69±0.28 vs girl=5.61±0.19 mmol/l), vs 4.71±0.33 mmol/l for non-T1DM (boys =4.55±0.32 vs girl=4.8±0.3 mmol/l); IL-6=1.72 ± 0.5 mmol/l, for T1DM (boys=1.71±0.57 vs girl=1.73±0.42mmol/l), vs 0.99±0.14 mmol/l for non-T1DM (boys=0.99±0.18 vs girl=1.0±0.12mmol/l); TNF-α=0.76± 0.14 mmol/l, for T1DM (boys=0.74±0.12 vs girl=0.78±0.15 mmol/l), vs 0.72±0.18 mmol/l for non-T1DM (boys=0.71±0.16 vs girl=0.73±0.2 mmol/l). HbA1c demonstrated a genuine statistical correlation of reasonable significance with IL-1β (r=0,60**, p< 0,001, IL-6 (r=0,58**, p< 0,001, and TNF-α (r=0,32**, p< 0,001). Conclusion. The current research assessed proinflammatory cytokines by quantifying the level of IL-1β, IL-6, and TNF-α. The level of these parameters was significantly higher in the pediatric subjects with T1DM than in the conditionally healthy ones, being consistent with the HbA1c level, respectively may be exploited as potential markers for the development of T1DM.