Introduction: Autism is a neurodevelopmental disorder characterized by disruptions in social interaction, communication, and behavior. Children with autism may exhibit aggressive and self-mutilating behaviors with a significant impact on themselves and their families. The aim of this study is analysis and synthesis of therapeutic strategies for reducing aggression and self-mutilation in these children. Methods: The study was carried out following the specialized literature, electronic databases such as: MEDLINE/PubMed, Google Scholar and PsycINFO, using the keywords: "autism", "aggression", "selfmutilation", "therapeutic strategies". We included empirical studies, meta-analyses published in the period 2018-2023. Results and discussions: Approximately 40% of children with autism exhibit aggressive behaviors, with an incidence of self-mutilation approximately 15%. ABA therapy reduces aggressive behaviors by approximately 60-70%, while cognitive-behavioral therapy reduces self-mutilating behaviors by approximately 50%. Augmentative and alternative communication devices improve communication in approximately 70% of cases, reducing aggressive behaviors. Occupational and sensory therapy has a positive impact in approximately 65% cases, reducing aggressive reactions associated with sensory sensitivity. Medications, such as antipsychotics or serotonin inhibitors, was effective in reducing aggression in 45-50% of cases. The analysis identified therapeutic strategies reducing aggression and self-harm in autistic children, with a 50-70% decrease. A personalized, multidisciplinary approach improves their quality of life.