Aim of study. Neoplasms of the colon have a very high probability of growth and the appearance of the following complications: hemorrhages, intestinal occlusions, but not least the development of colorectal cancer. Endoscopic diathermoexcision polypectomy is indicated for preventive purposes and remains a modern minimally invasive surgical solution for this contingent of patients. Materials and methods. The prospective study included 302 patients with benign and malignant neoplasms of different sizes of the colon, who underwent endoscopic polypectomy by diathermoexcision between 2018 and 2022, were aged between 19 and 89 years. The inclusion criteria of the study was the presence of neoplasms of the colon, predominantly 15-45 mm in size. Results. Among 302 patients enrolled in the study in 71.9% of cases (217 pts) polypectomy by diathermoexcision was performed in full volume. In the second group, 28.1% (85 pts) with large neoplasms required additional polypectomy in the period between 3 to 6 months. In the majority of cases n=181 (59.9 %) the histopathological examination confirmed tubular adenoma, in n=109 (36.2 %) cases - tubular-villous adenoma, in 12 (3.9 %) patients adenocarcinoma was detected. In case of adenocarcinoma, control colonoscopy was indicated after 3 months and the absence of neoplasm recurrences was confirmed. Major complications such as colonic perforation occurred in 4 (1.3%) patients, who were urgently operated. Intraoperative hemorrhages n=7 (2.1 %) were stopped endoscopically by endoclamation and diathermocoagulation. Conclusions. Endoscopic diathermoexcizion polypectomy is a method of choice for large colonic polyps with insignificant complication rate.