Introduction. Upper gastrointestinal bleeding from acute post-ligation ulcers is a rare complication of endoscopic banding, with high morbidity and mortality. Its incidence reported in the literature varies between 2.3-18%, the therapeutic management recommendations being absent or sporadic. The aim of the research was to analyze the impact of thrombin injection during endoscopic banding of esophageal varices on the bleeding rate from post-ligation ulcers. Material and methods. In the study cohort, consisting of 18 patients (5 of whom underwent repeated banding, in 4 patients banding was performed for active bleeding), thrombin injection was performed in a volume of 2.5 ml., a total of 250 units, in 2-4 paravariceal points. The injection was performed during endoscopic banding, adjacent to the hemorrhagic varix (acute hemorrhage) or the varix most suspected for rupture (primary or secondary prophylaxis). Results. One recurrence of bleeding (5.5%) was observed in the first 24 hours (banding was performed for active bleeding, the cause being the premature detachment of 2 bands out of 5 applied in total). In 17 patients, no recurrence was observed during the 28-day follow-up after banding. During the follow-up gastroscopy after 28 days, acute post-ligation ulcers at various stages of healing, as well as residual varices, were detected in these patients. Conclusions. The proposed method is reasonably applicable to patients who undergo repeated banding. It requires precise operator technique and a clearly visible injection point, which involves the initial cessation of the hemorrhage with the Sengstaken-Blakemore tube.