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![]() ARUTYUNOV, G., TARLOVSKAYA, E., ARUTYUNOV, A., BELENKOV, Yu., KONRADI, Aleksandra, LOPATIN, Yu., REBROV, Andrey, TERESHCHENKO, Sergey, CHESNIKOVA, Anna, AIRAPETYAN, G., BABIN, Aleksandr, BAKULIN, I., NOI, Autori, BUDU, Angela, PETROV, Liviu. Lipid profile in hospitalized patients with covid-19 depending on the outcome of its acute phase: Data from the international registry "dynamics analysis of comorbidities in SARS-CoV-2 infection survivors". In: Russian Journal of Cardiology, 2022, vol. 27, pp. 16-30. ISSN 1560-4071. DOI: https://doi.org/10.15829/1560-4071-2022-5042 |
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Russian Journal of Cardiology | |
Volumul 27 / 2022 / ISSN 1560-4071 | |
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DOI:https://doi.org/10.15829/1560-4071-2022-5042 | |
Pag. 16-30 | |
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Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry. Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation. Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of <2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C ([removed]. |
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Cuvinte-cheie cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triacylglycerol |
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