Introduction. It has been scientifically proven that there is an association between subclinical hypothyroidism (SCH) during pregnancy and hypertension in pregnancy, preterm birth and impaired cognitive development of children. There are data on the consumption of fluoridated drinking water and the development of subclinical hypothyroidism during pregnancy. Material and methods. Fluoride in drinking water increases the risk of subclinical hypothyroidism. The study conducted in Canada divided pregnant women into euthyroid (n=1301), with subclinical hypothyroidism (n=100) and primary hypothyroid (n=107). There were measured fluoride levels in consumed water and in some urine samples, and was estimated the impact of fluoridated water consumption on pregnant women in the described groups. In the Republic of Moldova, the data on the fluoride content, taken from the registers of the Public Health Centers, for the period 20102017, were analyzed. In the Republic of Moldova there are districts where the fluoride concentration essentially exceeds the normative limit. Results. Among women with normal antiTPO levels in Canada, the risk of primary hypothyroidism increased with increasing fluoride-containing water intake (OR water fluoride concentration: 2.85; 95% CI: 1.25, 6.50). At the same time, the data analysis of 150 pregnant women from different regions of the Republic of Moldova demonstrated the higher incidence of subclinical hypothyroidism in pregnant women living in districts where the fluoride content in the water is high (Ceadîr-Lunga, Ștefan-Vodă). Conclusions. Additional research is needed for the regions of the Republic of Moldova to establish the raport between fluoride in drinking water and subclinical hypothyroidism in pregnant women.