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SM ISO690:2012 GHERGHINA, Ioan, COVĂCESCU, Mirela, PASCU, Bogdan, CONSTANTIN, Andreea Teodora, KOZMA, Andrei. The importance of immunological investigations for the diagnosis of celiac disease. In: Perspectives of the Balkan medicine in the post COVID-19 era: The 37th Balkan Medical Week. The 8th congress on urology, dialysis and kidney transplant from the Republic of Moldova “New Horizons in Urology”, Ed. 37, 7-9 iunie 2023, Chişinău. București: Balkan Medical Union, 2023, Ediția 37, p. 150. ISSN Print: ISSN 1584-9244 ISSN-L 1584-9244 Online: ISSN 2558-815X. |
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Perspectives of the Balkan medicine in the post COVID-19 era Ediția 37, 2023 |
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Congresul "Perspectives of the Balkan medicine in the post COVID-19 era" 37, Chişinău, Moldova, 7-9 iunie 2023 | |
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Pag. 150-150 | |
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Celiac disease (gluten intolerance) is a condition with an immune mechanism triggered and maintained by the ingestion of gluten in genetically predisposed individuals. The consumption of gluten by intolerant people leads to damage to the small intestine through the destruction of enterocytes, a condition called gluten enteropathy. The incidence of this disease worldwide is 1:100 people. Symptoms in celiac disease vary, affected individuals may be asymptomatic or extraintestinal symptoms may predominate. Three observations were included in the study with subjects who had IgA type anti-transglutaminase antibodies above 200 μm. The particularities of the studied cases are the late diagnosis, the high values of antitissue transglutaminase type IgA antibodies that allowed, according to international guidelines, diagnosis without biopsy, to which is added the age under 3 years. Physiological personal antecedents are insignificant From the pathological personal antecedents we mention developmental disorder, raising the suspicion of autistic spectrum disorder, does not speak, attention deficit. At the clinical examination we mention dry skin, poorly represented subcutaneous cellular tissue, weathered abdomen, otherwise balanced on devices and systems. Routine analyzes revealed non-specific changes. The positive diagnosis was established by the dosage that had values 10 times higher than normal. However, the determination of anti-endomysium antibodies would also have been necessary. After more extensive biological investigations in the studied subjects, for the safety of the diagnosis, it was proposed to the family to perform an intestinal biopsy. The results confirmed the clinical and immunological diagnosis of celiac disease based on the intestinal lesions that they considered compatible with the diagnosis of celiac disease (Marsh score 3b), in the appropriate clinicoserological context. Eliminating gluten from the diet was followed by a spectacular improvement in symptoms. |
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