Introduction. Ameloblastoma is a benign tumour of odontogenic origin, whose structure similar to the enamel organ, which originates from epithelial tissue and is characterised by an invasive, locally destructive growth. Early detection as and minimally invasive surgical treatment are the concerns of specialists in the domain who are working on to reduce the invalidating consequences of the pathology. Material and methods. Patient V. A., F/ 58 years old, was referred to the stomatological clinic: ,,Omni Dent'' presenting functional and aesthetic complaints. Clinical and radiological manifestations showed bone destruction in the left mandibular body with the presence of tooth mobility and innervation disorders. The established diagnosis was: "Chronic osteomyelitis of the mandible on the left region of the body". Results. Was performed the operation of sequestrenecrectomy, and only after histological examination follicular ameloblastoma has been identified. Was performed operation of segmental excision of the mandible, restoration with reconstructive titanium plate and subsequent implant prosthetic rehabilitation with four remote implants in intact bone. One-year dynamic followup demonstrated the efficacy of the applied methods, lack of complications and acceptable outcome. Conclusions. Clinical detection without accentuated manifestations, diversity of histological structure of ameloblastoma is the basis for diagnostic errors, accordingly, at the stage of final planning of surgery is a necessary condition the use not only of computed tomography scanning but also histological examination.