The paper is a follow-up of two other rather recently published articles [1] and [2] that were meant to present a concise and rather fair image of computer-supported human wellbeing, resilience, and collaborative decision-making. Since the publication of the above papers (in December 2021, and March 2022, respectively), many significant technology advances, real-world applications, and intellectual debates have been noticed. The present paper builds upon the basic aspects previously presented, and an attempt is made to zoom in on the updated information about Artificial-Intelligence (AI) disrupting progress and three pacing technologies, namely, digital cognitive systems, chatbots, and digital platforms. In the first part of the paper, the basic aspects concerning automation, digital wellness, human resilience, and various forms of collaboration are reviewed. Several traditional and new applications of automation and AI-based tools and systems in both professional and personal life of the people are described. For example, creating the premises for a digital proximity and access to GLAM (galleries, libraries, archives, museums) with a view to improving the knowledge base and quality of the cultural life of the human is presented and illustrated by an application in the Library of the Romanian Academy. The original Fitts’ MABAMABA (Men Are Better At-Machines Are Better At) list, and its views of several influential personalities such as Douglas Engelbert, Joseph Carl Robnett Licklider, Peter Ducker, Umberto Eco, and Herbert Simon about human-technology interaction and influences are reminded. A particular attention is paid to the mutualistic synergy of humans and digital artifacts and the original declarative model of the experienced decision-maker as an early anticipatory version of the current digital clones of human actants is evoked. The second part of the paper addresses the recent developments of AI-based tools and systems and their deployment that are intended to improve the human physical wellness and make the work easier, more comfortable and even pleasant. A particular emphasis is put on the technology developments and business models stimulated by the constraints caused by the recent pandemic. The new attempts and results meant to automate human intellectual functions such as the creation of AGI (Artificial General Intelligence) are reviewed together with the revolutionary results of the very innovative technology giants such as Deep Mind and OpenAI. The early debates on automating human’s intellectual functions and the corresponding consequences on people are illustrated by the opposed views of Hubert Lederer Dreyfuss, a philosopher, and Ray Kurzweil, a computer scientist and futurist. The presentation continues with the rather consonant, not too optimistic, evaluations and predictions of Stephan Hawking, Elon Musk, Bill Gates, Steve Wozniak, Ian Hogarth, and Noah Harari. The section concludes with a presentation of several current initiatives and efforts made with the view to ensure observing the ethic requirements in the development and deployment of the new digital artifacts. The third part of the paper surveys several recent developments meant to make the life of the people more comfortable and the collaboration smoother and more effective. Three particular technology domains are discussed as: a) digital cognitive systems within a service-oriented architecture proposed by Jim Spohrer of IBM, b) chatbots and the current “battle of wordsmiths” of the emergent or well-established competitor firms, and c) the widespread of platform-based workstyle. The concluding part of the paper is concerned with the concept of Digital Humanism and associated works and events. The section starts by presenting several identified undesirable evolutions of the technologies and the associated business models. Then it surveys the early and rather surprising views of the Sorbonne professor Milad Doueihi on the “quatrième humanisme numérique”, followed by the pragmatic and business-oriented manifesto of Gartner, the influential work of the German philosopher Julian Nida Rümelin and his colleague Nathalie Weidenfeld, and the rather recent Digihum (Digital Humanism Initiative), Vienna Manifesto, and the series of activities at T.U. Vienna that are only a few significant milestones in an ever growing movement aiming at defining and creating the premises for a set of recommendations and actions meant to compensate the downside of technology advances.