Introduction: Chronic pain dramatically affects moods, feelings, and emotions. Similar effects are also induced by colours. The hypothesis was whether the preferred color influences pain prevalence after 6 monts postoperatively. Material and methods: Prospective, consecutive study. Institute of Emergency Medicine, Chisinau, Republic of Moldova. Intervention: scheduled hip replacement. Research Ethics Committee approved. Exclusion criteria: color blindness, pre-existing chronic pain, depression, anxiety, neuropathy. Preferred colours registered according to the CMYK (cyan, magenta, yellow, and key [black]) system. Patients phoned over 6 months and asked whether or not they have pain (≥3 NRS - Numeric Rating Scale - points). Statistical analysis: Fisher’s exact test. Data are presented as absolute (relative values). Results: Enrolled 217 ASA (American Society of Anesthesiologists) 2 and 3 patients (93/42.9% men). Age 65.7 ± 12.7 years. At 6 months, response rate was 96/217 (44.2%). Pain (≥3 NRS) was reported by 59/96 (61.5%) of patients. Next, the proportion of patients with no pain vs. with pain at 6 months, according to their preferred color, is presented: blue 3 (8.1%) vs. 5 (8.5%) (p = 1.0000); majenta 1 (2.7%) vs. 8 (13.6%) (p = 0.1467); cyan 13 (35.2%) vs. 12 (20.4%) (p = 0.1514); white 1 (2.7%) vs. 4 (6.8%) (p = 0.6458); red 7 (18.9%) vs. 7 (11.9%) (p = 0.3832); yellow 3 (8.1%) vs. 3 (5.1%) (p = 0.6730); green 7 (18.9%) vs. 18 (30.3%) (p = 0.3823); black 2 (5.4%) vs. 2 (3.4%) (p = 0.6379). Conclusion: Preference for a particular colour does not seem to influence the prevalence of chronic pain 6 months after hip joint replacement. Since some categories tend towards statistical significance, larger batches of patients are needed for definitive testing of the given hypothesis.