Background: The Midline lumbar interbody fusion (MIDlIF) using the cortical bone trajectory (CBT) pedicle screws was recently proposed as an alternative method to the traditional fusion techniques. The CBT screw follows a mediolateral path in the transverse plane and caudocephalad path in the sagittal plane. The entry point is located closer to midline, on the pars interarticularis. This technique is less invasive, improves screw−bone purchase and reduces approach-related morbidity. Method: Between January 2016 and January 2017, 36 patients (14 men and 22 women) underwent midline lumbar interbody fusion for degenerative disorders of the lumbar spine. The procedure included bilateral total facetectomy, bilateral intervertebral cage insertion and CBT pedicle screw fixation of the spine. The l3 to S1 levels were instrumented, the l4-l5 being the most frequently fused level. For S1 screws, we used the penetrating S1 endplate technique. Results: We obtained good postoperative results in all cases. Considerable improvement in both back and leg pain was achieved. The most frequently encountered complication was the pedicle fracture at the screw insertion site (6 cases). The mean operation time, blood loss was and postoperative morbidity were significantly lower than in the traditional lumbar fusion surgery. We observed considerable improvement in VaS, SF-12 and oDI scores comparing to traditional techniques. We present early clinical results of a new technique that appeared to have a better fixation profile in laboratory testing. Conclusion: The MIDlIF represents a good alternative option to obtain decompression and a solid fixation of the spine through a single minimally invasive procedure.