Infection with the new type of coronavirus SARS-CoV-2 is a real challenge for the entire medical and scientific community. It forces the health care institutions to deal with a record number of patients, and often, there are contradictory statements about this virus because of its chameleonic features. As the COVID-19 pandemic continues to expand, several clinical cases with the multisystem inflammatory syndrome in children (MIS-C) similar to the Kawasaki disease have reported in many studies. The exact pathophysiological mechanisms are still unknown, but most children have multiple organ dysfunctions, while respiratory damage is less pronounced than adults. Typical clinical manifestations of MIS-C include fever and impairment to two or more organ systems, with evidence data of inflammation and laboratory or epidemiological evidence of SARS-CoV-2 infection. The present paper describes the clinical manifestations of 5 clinical cases with Kawasaki disease that met the criteria for the MIS-C case definition issued by the WHO.