Background. There are not many studies devoted to the study of the structural organization of the glands of the human prostate in its various structural lobes in terms of age in childhood and adolescence. Many issues of prostate morphology remain unclear during childhood. The aim of the study was to study the age-related changes of the epithelium and the end pieces of the prostate main glands, in all its structural lobules in the age range from childhood to teenager age. Materials and methods. Histological, morphometric methods were used to study the secretory epithelial cells and the end pieces of the main glands on prostate preparations of 24 boys aged 1-17 years, on autopsy material. Shape and sizes of the secretory epithelial cells and the end pieces of the prostate main glands in pairs of anteromedial, superomedial, inferoposterior, inferolateral structural lobes were determined. Results. Significant morphological transformations of the prostate glands, such as an increase in the height of the secretory epithelium of the main glands, the size of the terminal sections of the glands, occur in adolescence. At the same age, there is a difference in the morphology of the glands in different structural lobules of the prostate. Conclusions. The prostate remains largely dormant until puberty when there are significant changes in prostate gland morphology due to pubertal burst.