The coordination compound [Co(DH)₂(PP)₂][BF ₄]₂ • 2H₂O (DH^- is the dimethylglyoxime residue, PP is nicotinamide) was synthesized and studied by X-ray diffraction. The equatorial plane of the octahedral Co(III) complex contains two DH^- residues combined by intramolecular hydrogen bonds O-H⋯O, while the apical positions are occupied by two PP molecules. A method for the optimal use of the complex for enhancement of the biosynthesis of standard and acid-stable amylases of the micromycete Aspergillus niger 33-19 CNMN FD 02A and lipases of the micromycete Rhizopus arrhizus Fischer CNMN FD 03L was depeloped. The introduction of the complex in a concentration of 1-5 mg/l into the culture medium of Aspergillus niger 33-19 CNMN FD 02A reduces the process cycle by 24 h. The stimulating effect of the introduction of the complex (5 mg/l) into the culture medium of the Rhizopus arrhizus Fischer CNMN FD 03L strain is 55.5%.