Hypertension and diabetes are components of metabolic syndrome. The coexistence of these two diseases is associated with increased risk of cardio-vascular events. The microvascular and macrovascular complications are signi-ficantly more common unfavourable cardiovascular events. The first line of anti-hypertensive drug classes includ angiotensin-converting enzyme inhibitors, an-giotensin receptor blockers, calcium channel blockers, thiazide-like diuretics, mi-neralocorticoid receptor antagonists, and beta-blockers. The second-line anti-hypertensive drugs include α-blockers, renin inhibitors, loop diuretics, substan-ces affecting the central nervous system (methyldopa, clonidine), and vasodila-tors. The exact choice of hypotensive drugs depends on various factors: comorbi-dities, estimated glomerular filtration rate, side effects and ethnicity.