Correlation between levels of some serum markers and instent restenosis development Although significant progress has been made in the prevention and treatment of instent restenosis, it remains an unsolved clinical problem of interventional cardiology. The restenosis rate with bare metal coronary artery stents is about 15-20% and with drug eluting stents – 3-8%. Some studies revealed that instent restenosis may be an independent predictor factor of four-year mortality after stent implantation. The triggers and pathophysiological mechanisms of instent restenosis are not completely elucidated.

Deşi progrese semnificative au fost înregistrate în prevenirea şi tratamentul restenozei intrastent (RIS), totuşi ea rămâne o problemă a cardiologiei intervenţionale. Rata RIS în cazul stenturilor metalice este de 15-20% şi în cazul stanturilor farmacologic active - 3-8%. Unele studii au relevat că RIS reprezintă un predictor independent de mortalitate la 4 ani după stentare. Triggerii şi mecanismele patofiziologice ale RIS nu sunt pe deplin elucidate.