Identification, quantitative determination and isolation of pomolic acid from lavender (Lavandula angustifolia Mill.) wastes
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GÎRBU, Vladilena, ORGAN, Adina, GRINCO, Marina, COTELEA, Tamara, UNGUR, Nikon, BARBA, Alic, KULCIŢKI, Veaceslav. Identification, quantitative determination and isolation of pomolic acid from lavender (Lavandula angustifolia Mill.) wastes. In: Sustainable Chemistry and Pharmacy, 2023, vol. 33, p. 0. ISSN 2352-5541. DOI: https://doi.org/10.1016/j.scp.2023.101140
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Sustainable Chemistry and Pharmacy
Volumul 33 / 2023 / ISSN 2352-5541

Identification, quantitative determination and isolation of pomolic acid from lavender (Lavandula angustifolia Mill.) wastes

DOI:https://doi.org/10.1016/j.scp.2023.101140

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Gîrbu Vladilena1, Organ Adina2, Grinco Marina1, Cotelea Tamara2, Ungur Nikon1, Barba Alic1, Kulciţki Veaceslav1
 
1 Institute of Chemistry, MSU,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
 
Disponibil în IBN: 6 iunie 2023


Rezumat

Lavender essential oil production wastes have been investigated as a highly available source of pentacyclic triterpenic acids. Ultrasound assisted extraction was addressed as a simple and scalable procedure for efficient production of enriched extracts from dry plant material with good yields. Flowers and stalks have been processed separately. Analytical studies have been performed basing on both HPLC and qNMR methods. The qNMR analysis proved to be a much more convenient alternative to HPLC and its application resulted in identification, isolation and quantitative determination of substantial amounts of pomolic acid in the obtained extracts, along with widely explored ursolic and oleanolic acids. The ultrasound assisted extraction of lavender flowers with 96% ethanol resulted in a 3.3% yield of triterpenic acids, with a substantial share of pomolic acid that constitutes 1% of the plant material dry weight. Selective extraction of flowers with ethylacetate resulted in an enriched product containing 67.8% of triterpenic acids, including 16.2% of pomolic acid. Quantification of pomolic acid is reported for the first time in this vegetal source. These results demonstrate the relevant potential of lavender wastes as a sustainable raw material for the production of pomolic acid - a highly valued compound of increased nutraceutical and pharmaceutical interest.

Cuvinte-cheie
Lavandula angustifolia, Pomolic acid, qNMR, Triterpenoids, Ultrasound assisted extraction