Comparative features and outcomes of major neurological complications of COVID-19
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Инфекционные заболевания. Инфекционные лихорадки (587)
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BEGHI, Ettore, MORO, Elena, DAVIDESCU, Eugenia Irene, NOI, Autori, GROSU, Oxana. Comparative features and outcomes of major neurological complications of COVID-19. In: European Journal of Neurology, 2023, nr. 2(30), pp. 413-433. ISSN 1351-5101. DOI: https://doi.org/10.1111/ene.15617
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European Journal of Neurology
Numărul 2(30) / 2023 / ISSN 1351-5101 /ISSNe 1468-1331

Comparative features and outcomes of major neurological complications of COVID-19

DOI:https://doi.org/10.1111/ene.15617
CZU: 616.9-06-036.21:578.834

Pag. 413-433

Beghi Ettore1, Moro Elena2, Davidescu Eugenia Irene34, Noi Autori, Grosu Oxana5
 
1 IRCCS - 'Mario Negri' Institute for Pharmacological Research, Milan,
2 Grenoble Alpes University,
3 Colentina Clinical Hospital,
4 University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
5 Diomid Gherman Institute of Neurology and Neurosurgery
 
 
Disponibil în IBN: 12 ianuarie 2023


Rezumat

BACKGROUND AND PURPOSE: The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations. METHODS: The data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors. RESULTS: By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome. CONCLUSIONS: Patients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19.

Cuvinte-cheie
Coronavirus, COVID-19, neurological complications, neurology

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