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SM ISO690:2012 ȘOLTOIANU, Dana, DIUG, Eugen, CIOBANU, Nicolae, GURANDA, Diana, CIOBANU, Cristina. Technologies for formulation of nanoparticulated phytopreparations. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 499. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 499-499 | ||||||
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Background. In recent years, there has been a growing interest in research into the incorporation of biologically active compounds extracted from plants into nanoparticulate delivery systems (NDSs), which have been shown in clinical trials to effectively increase their therapeutic bioavailability. Objective of the study. Study of technologies and principles for obtaining nanoparticles loaded with medicinal plant extracts. Material and Methods. The descriptive and analytical study of the literature was performed using electronic databases such as Scopus, PubMed and EBSCO. Results. Nanoformulation offers advantages for improving bioavailability, increasing solubility, permeability, metabolic change, and ligand specificity for the incorporated active substances. By evaluating the results of published research with reference to gold, selenium, carbon, silicate, magnetic, polymeric, and other technologies for NDSs, obtained by synthesis through physical and chemical methods, the disadvantage of these methods due to high cost and biosecurity challenges has been identified. This foster the development of green technology for obtaining NDS by using plant extracts, conditioned by the most optimal methods of extraction of phytocomponents such as: ultrasonic assisted extraction, microwave, Soxhlet extraction, supercritical carbon dioxide and enzymatic extraction, which offers yields between 80-100%. Conclusion. The production of nanoparticulate phytopreparations is in the stage of continuous research and requires an extensive study of the mechanism of use of secondary plant metabolites, physicochemical parameters and synergistic response with the specific receptor. |
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Cuvinte-cheie Phytopreparation, formulation, nanoparticle, fitopreparat, formulare, nanoparticulă |
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