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SM ISO690:2012 MOLDOVAN, Irina, NICU, Olesea, STASII, Ekaterina. Molecular diagnosis of milk allergy in children and correlation with the evolution of atopic dermatitis. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 392. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 392-392 | ||||||
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Background. Cow’s milk protein allergy (ACMP) is a problem in modern pediatrics, as it often occurs in the first months of a child’s life and can affect the formation of severe allergic diseases at an older age. Objective of the study. Study of the correlation between the diagnosis of Ig-mediated APLV in children and the evolution of atopic dermatitis. Material and Methods. The study included 30 children with ACMP, with the application of the survey, which included anamnestic data, the results of laboratory examinations. The ALEX molecular assay was used for the molecular diagnosis of ACMP. The severity of atopic dermatitis in children was assessed by the SCORAD index. Results. 70% were children <2 years old. In assessing the values of allergens in cow’s milk, α-lactalbumin and β-lactoglobulin predominated in 75% of cases, followed by 50% casein and serum albumin in 20% of cases. In 60% of cases, polysensitization was found with high specific IgE values towards cow’s milk proteins and other food allergens (eggs, fish, nuts). In the group of patients with poly sensitivity to food allergens, patients with a SCORAD index greater than 50 were more common, compared to the group of patients with mono-sensitization. Conclusion. ACMP is a major cause of development of atopic dermatitis in children < 2 years of age. Assessment of sensitization to food allergens at the molecular level allows the identification of patients with a high probability of developing severe forms of atopic dermatitis. |
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Cuvinte-cheie children, atopic dermatitis, allergens, APLV, copii, dermatită atopică, alergeni |
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