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Ultima descărcare din IBN: 2023-01-03 16:45 |
Căutarea după subiecte similare conform CZU |
616-089.843:611.018 (5) |
Патология. Клиническая медицина (6964) |
Анатомия. Анатомия человека. Сравнительная анатомия (237) |
SM ISO690:2012 CEBOTARI, Ion, VIZIR, Daniela, CHEPTANARU, Eduard. The maintenance of the organs viability for transplantation by applying ex-vivo methods of reconditioning or treatment. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 327. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616-089.843:611.018 | ||||||
Pag. 327-327 | ||||||
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Background: Advanced organ failure is considered the terminal stage of the disease, in which curative options are limited to targeted treatment of the organ by ex-vivo approach. This method can solve the global problem of organs deficiency. Objective of the study. Presenting the benefits of the ex-vivo approach for organs with injured function, in patients with absolute indications for organ transplantation. Material and Methods. It has been studied the available articles on PubMed and Medscape, published between 2000-2021. Methods of organ prelevation, preparation for extracorporeal circulation, the maintenance of the tissue viability in ex-vivo conditions, the application of targeted treatment in severe infections/tumors and tissue revitalization post-injury, have been analyzed. Results: The benefit of the ex-vivo approach to any organ is the extended therapeutic range compared to the in-vivo approach. Ex-vivo organs reconditioning before transplantation can be performed by several methods. One of them would be targeted drug treatment with high therapeutic doses, which in conditions with standard in-vivo doses have not proven to be effective. Surgical removal of hard-to-reach tumors, their irradiation with high doses of radiation and/or chemotherapy followed by autotransplantation, can be performed too. Another usage of this method would be the revitalization of the lungs that do not meet the mandatory criteria for transplantation, with STEEN solution. Conclusions: The application of ex-vivo treatment in the case of patients suffering from terminal stage diseases, will allow them a more rapid access to a viable and suitable organ, which will increase their life expectancy. |
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Cuvinte-cheie ex-vivo organ treatment, autotransplantation, ex-vivo reconditioning, tratarea organelor ex-vivo, autotransplantare, recondiționare ex-vivo |
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