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Căutarea după subiecte similare conform CZU |
611.018.74:616.5-002.52 (1) |
Анатомия. Анатомия человека. Сравнительная анатомия (240) |
Заболевания мочеполовой системы (211) |
![]() SONDOS, Abed. Endothelial dysfunction in systemic lupus erythematosus. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 226. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 611.018.74:616.5-002.52 | ||||||
Pag. 226-226 | ||||||
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Introduction: The endothelium is a crucial regulator of vascular homeostasis; lupus-associated chronic systemic inflammation may compromise endothelial functioning, triggering a chain of events that, when combined with established CVD risk factors, leads to the formation and progression of atherosclerosis. Aim: To assess how SLE affect the function of endothelium. Methods: We have performed a database search of all relevant literature published until June 2022. The search included English written articles. Electronic databases including PubMed, Oxford Academics, Google Scholar were searched using the following terms: “SLE + endothelium dysfunction”. Results: The search yielded 17 articles, out of which 11 articles were considered relevant published from 2002 to 2022. Out of 11 articles, 2 were literature reviews and 9 cross sectional and case control studies including a total number of 439 SLE patients. To date, the vast majority of available data, albeit not all, indicates that endothelium dependent FMD values are lower in SLE patients compared to healthy subjects; however, additional studies will be required to confirm the usefulness of endothelial dysfunction quantification as a CVD predictor in the specific clinical setting of lupus. Notably, FMD variations can be used to assess certain therapy methods’ capacity to improve endothelial function in SLE patients. Conclusion: Endothelial function appears to be affected by SLE potentially contributing to the increased cardiovascular risk observed in SLE patients. |
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Cuvinte-cheie endothelium, flow-mediated dilatation, systemic lupus erythematosus, endoteliul, dilatare mediată de flux, lupus eritematos sistemic |
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