Sunflower cultivation is an important component of the food industry. It is grown all over the world and therefore has a wide range of pathogens that can affect it. As phytosanitary treatments are not always effective and economical, the cultivation of disease-resistant hybrids is the main measure for both optimal yields and environmental protection. Botrytis cinerea Pers. is a pathogen that causes quality depreciation of production to a wide range of plant species used in human nutrition. The pathogen attacks the sunflower seeds that lose their taste qualities, the latter being decisive in terms of using the product in the food industry. The paper aimed to observe the behavior of some sunflower hybrids to the attack of the pathogen Botrytis cinerea, in the climatic conditions of the South-East area of Romania in 2021. To make the observations, the biological material used was represented by nine hybrids created at the National Institute for Agricultural Research and Development-Fundulea, cultivated in climatic stress conditions. The experiment took place within the Agricultural Development Research Station-Braila, Chiscani Experimental Field, in 2021. The hybrid H5 stood out through its low degree of attack of 1,41% compared to the average degree of attack of 2.27%. The weakest behavior regarding the pathogen attack was observed in the hybrid H4, with a degree of attack of 2.6%.