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Articolul precedent |
Articolul urmator |
231 0 |
Căutarea după subiecte similare conform CZU |
616.831.3-009:616.832-004.2-06 (1) |
Инфекционные заболевания. Инфекционные лихорадки (971) |
SM ISO690:2012 CIOLAC, Dumitru, GONZALEZ-ESCAMILLA, Gabriel, WINTER, Yaroslav, LUESSI, Felix, RADETZ, Angela, FLEISCHER, Vinzenz, GROPPA, Stanislav, BITTNER, Stefan, ZIPP, Frauke, MUTHURAMAN, Muthuraman, MEUTH, Sven G., AUTOR, Nou, GROPPA, Sergiu. Altered grey matter integrity and network vulnerability relate to epilepsy occurrence in patients with multiple sclerosis. In: European Journal of Neurology, 2022, nr. 8(29), pp. 2309-2320. ISSN 1351-5101. DOI: https://doi.org/10.1111/ene.15405 |
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European Journal of Neurology | |
Numărul 8(29) / 2022 / ISSN 1351-5101 /ISSNe 1468-1331 | |
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DOI:https://doi.org/10.1111/ene.15405 | |
CZU: 616.831.3-009:616.832-004.2-06 | |
Pag. 2309-2320 | |
Rezumat | |
Background and purpose: The aim of this study was to investigate the relevance of compartmentalized grey matter (GM) pathology and network reorganization in multiple sclerosis (MS) patients with concomitant epilepsy. Methods: From 3-T magnetic resonance imaging scans of 30 MS patients with epilepsy (MSE group; age 41 ± 15 years, 21 females, disease duration 8 ± 6 years, median Expanded Disability Status Scale [EDSS] score 3), 60 MS patients without epilepsy (MS group; age 41 ± 12 years, 35 females, disease duration 6 ± 4 years, EDSS score 2), and 60 healthy subjects (HS group; age 40 ± 13 years, 27 females) the regional volumes of GM lesions and of cortical, subcortical and hippocampal structures were quantified. Network topology and vulnerability were modelled within the graph theoretical framework. Receiver-operating characteristic (ROC) curve analysis was applied to assess the accuracy of GM pathology measures to discriminate between MSE and MS patients. Results: Higher lesion volumes within the hippocampus, mesiotemporal cortex and amygdala were detected in the MSE compared to the MS group (all p < 0.05). The MSE group had lower cortical volumes mainly in temporal and parietal areas compared to the MS and HS groups (all p < 0.05). Lower hippocampal tail and presubiculum volumes were identified in both the MSE and MS groups compared to the HS group (all p < 0.05). Network topology in the MSE group was characterized by higher transitivity and assortativity, and higher vulnerability compared to the MS and HS groups (all p < 0.05). Hippocampal lesion volume yielded the highest accuracy (area under the ROC curve 0.80 [0.67–0.91]) in discriminating between MSE and MS patients. Conclusions: High lesion load, altered integrity of mesiotemporal GM structures, and network reorganization are associated with a greater propensity for epilepsy occurrence in people with MS. |
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Cuvinte-cheie epilepsy, grey matter integrity, lesion load, multiple sclerosis, network vulnerability |
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