In recent years, the Government of the Republic of Moldova has made considerable efforts to boost the development of the SME sector and has increasingly recognized the role of innovation as a key driver of a competitive and sustainable economy. And although strategic policy documents, programs, and other normative-legal acts, aimed at stimulating the elaboration and implementation of innovations have been developed and adopted at the national and regional levels, the political commitment to the implementation of innovation policy has remained limited and the innovation ecosystem remains at an incipient phase. In this context, in order for innovative entrepreneurship to develop effectively and be able to fully contribute to economic growth and development, it is suggested that its importance be further recognized. The aim of this paper is to present an overview of the legislative framework and policy documents to support innovation at the national and regional levels - derived from other policy areas, highlighting the fact that the integration of the innovation policy for entrepreneurship in existing policy areas is problematic. In the article, the author also identifies and analyzes the determinants of innovative entrepreneurship, available for the Republic of Moldova and comes with some recommendations on boosting the development of innovative entrepreneurship in the country, the main suggestion being the emergence of an innovation strategy with the participation of all stakeholders in innovation and entrepreneurship. Methods such as analysis and generalization (of the legislative acts and policy documents, economic and statistical indicators, and other analytical materials) were used in the elaboration of the article.