The purpose: Analysis of pemphigus vulgaris actuality in Dermatology to identify future directions for research and develop new experimental approach wich open new perspectives in the development of innovative therapeutic methods for these patients. Materials and methods: A patient of 65 years with pemphigus vulgaris Results: By the histological investigations with hematoxylineosin and picrofuscin of the tissues of a 65 years old patient with pemphigus vulgaris made in the morphopathologhy laboratory of the Republic Hospital of Traumatology and Orthopedics it was found the systemic damage of internal organs in this pathology. Microscopically it was observed: keratinocytes with a rounded contour, separated by the supra-basilar intraepidermal acantolysis; intravesicular necrotic keratinocytes, the vacuolar dermatitis of the interface in dermo-epidermal junction; the foci of the inflammatory reaction with lymphocytes, sometimes eosinophils and neutrophils and the sclerosis sectors in the internal organs. Conclusion: The bullous and ulcerative-erosive changes of skin and the mucous membranes are the hallmarks of the disease. Histological findings suggest that pemphigus vulgaris is a disease of the whole body, which can manifest a rich symptomatology, which speaks for that the disease is not strictly dermatological. This involves a vicious cycle of systemic degenerative and decompensated changes with an irreversible character, which increases mortality of pacients. Pemphigus vulgaris is an autoimmune disease with the chronic character affecting the skin and mucous membranes, forming multiple vesicles with the tending of well-proven histologic inflammation, initial with the involving of the epidermis then being untreated it has an infiltrative spread that includes all layers of the skin and internal organs, requiring a special contribution in the prevention and treatment of this disease. The pemphigus vulgaris pathology occupies the main places among the leading causes of the invalidity in the dermatological diseases, requiring the immunosuppressive therapy. Corticosteroids, immunosuppressive agents have remained the pillar of therapy in patients with pemphigus vulgaris in spite of adverse effects. Under conditions of current therapy, the prognosis of desease depends primarily on patient response to corticosteroids and the complications that they induce long-term administration. In order to develop new therapeutic strategies in pemphigus vulgaris we analysed the literature regarding the modeling of pemphigus vulgaris in the experimental animals to study the disease evolution and the identification of some new methods of the treatment before applying them in humans. We review some mouse models that allow for investigation of one or more steps of pathogenic events occurring in pemphigus vulgaris. Analysis of data from the literature on these models that reproduce the findings in pacients with autoimmune bullous skin diseases, offers the possibility to identify the future directions for research and to develop new experimental approach that opens new perspectives in the development of innovative therapeutic methods for these patients. This may to help to development of cell-based therapy of autoimmune skin blistering disease. Hence, in order to reestablish the disturbed immune self-tolerance, as a strategy, it is discussed about the integrating possibility of hematopoietic stem cell transplantation in the treatment of corticosteroid-resistant pemphigus vulgaris.