Global chemical pollution of the biosphere raises reasonable concern about possible violations of environmental and ecological balance in some parts of the biosphere. Particularly dangerous are synthetic compounds discarded in the nature as a result of human economic activity. Preparations obtained from microorganisms usually relatively safe for the biosphere, as they are organic. Our research conducted in several directions. To implement the tasks, the screening of microorganisms - producers of some substances was carried out, as well as transformers of complex chemical compounds, in particular, sclareol the labdane diterpenoid, obtained when extracting essential oil from the plant mass sage Salvia sclarea L. In determining the carbohydrate composition of algae Dunaliella salina and Spirulina platensis, we have received the preparations from the culture liquid (CL) and biomass. It was verified the biological activity of these preparations [1]. In the process of research, to expand the range of useful properties of microorganisms, we studied their antimicrobial activity against some pathogens, including the wine grapes phytopathogens (micromycetes Aspergillus niger, Alternaria alternata, agent of grey rot of grapes Botrytis cinerea, agent of white rot of grapes Sclerotinia sclerotiorum; bacteria Agrobacterium tumefaciens) and others. The study of antibiotical properties was based on the ability of substances to diffuse in agar plate and influence the tested phytopathogen [2, 3]. It was revealed, that under the influence of the preparation from the biomass of algae D. salina the growth of A. niger was suppressed. Zone of the negative impact was extended up to 16 mm in diameter. In this case the fungus is characterized as sensitive. Products derived from S. platensis biomass and CL inhibited the growth of microscopic fungi A. alternata. Areas in which there was a delay of growth of phytopathogen, reached 29.5 mm, which demonstrates the high sensitivity of the test-culture to preparations. As a result of screening of microorganisms capable to biotransformate sclareol, was isolated microscopic fungus identified as Penicillium camemberti Thom, Raper a.Thom CNM-FP-03, actively utilizing sclareol as the unique source of carbon. It was found that under certain conditions, the degradation of sclareol by fungi P. camemberti was accompanied by the formation of three major and two non-polar sclareol derivatives. We conducted a study on the impact of these compounds on the growth of phytopathogens. It was revealed that the test-cultures had been resistant to the effects of natural products of P. camemberti. Complex of non-polar metabolites caused inhibition of Pseudomonas syringae, Corynebacterium citri, Erwinia carotovora, inhibition of growth of A. tumefaciens (up to 13,0 mm). Quite a high antimicrobial effect was observed under the action of polar sclareol metabolites against phytopathogenic micromycetes A. alternata (diameter of lysis area - more than 23.0 mm). Special attention is the product of sclareol transformation - non-polar dimer A-5 (chemical formula C20H22O7), selected from a non-polar fraction of hydroxylated metabolites [4]. The negative sensitivity of the test-cultures (13,0-15,2 mm) was accompanied by prolonged action. The duration of suppression of phytopathogen microorganisms by solution of dimer A-5 was up to 40 days or more. Thus, our studies confirm the antimicrobial properties of the studied microorganisms and their metabolites and demonstrate the perspectives of their use in phytotechniques.