Chronic viral hepatitis in the Republic of Moldova presents a very serious socio-economic problem for public health and is one of the main causes of morbidity and mortality among the working population. AIM: The study and comparison of biochemical parameters, namely the determination of cytolysis syndrome (ALT, AST) and the ceruloplasmin level in blood serum in patients with chronic viral hepatitis of the HBV, HCV, HBV + HCV etiology. Ceruloplasmin (CPL) is known acute inflammatory phase glycoprotein, synthesized by the liver that transports about 95% of copper in blood serum, is involved in iron metabolism, possessing ferrooxidase activity and prevents the formation of oxygen free radicals. MATERIALS AND METHODS: We evaluated 138 patients with chronic viral hepatitis, of working age 48.35 ± 2.15, who were divided into 3 groups: group I - patients with chronic hepatitis (CH) of HBV etiology, n = 58, group II – CH of HCV etiology, n = 69 and group III constituted of patients with chronic hepatitis caused by a mixed viral infection of HBV + HCV, n = 11. RESULTS: A study of the cytolysis syndrome activity revealed an increase in serum ALT levels: presenting in 1st group 88.32 ± 10.38, (p< 0.01), in 2nd - 122.4 ± 9.78, (p< 0.01), in 3d -156 ± 32.16 (units / l), (p< 0.05) in comparison to the control group (20.4 ± 1.4 (units / l) The ceruloplasmin level in 1st - group elevated to 355.6. ± 8.4, (p< 0.05), in the second - 354 ± 8.0, (p<0.05), in the third - 354.16 ± 7.8 (mg / l, (p< 0.05), by comparison to the control group - 334.4 ± 5.6 (mg.L). A significant increase in CPL levels was observed in patients in all three groups compared to the control group, on the background of increased indicators of cytolysis syndrome. CONCLUSIONS. Evaluation of serum ceruloplasmin level in patients with chronic viral hepatitis could be usefull as one of the markers of chronic inflammatory process in the liver.